SJTRI’s scientific and
medical professionals are spearheading key preclinical
studies in a variety of areas, largely focused
on cardiovascular research. A few major study
areas of interest are listed below:
| Cardiac Electrophysiology |
- Arrhythmogenicity
of catheter-based skeletal myoblast injections
guided by
intracardiac echo in infarcted adult miniature
swine
|
- Transplantation of
autologous bone marrow mononuclear cells
does not alter arrhythmia threshold
|
- Epicardial fibroblast
injection modifies electrical conduction
in atrial myocardium
|
- Autologous fibroblast
transplantation into myocardial infarcts
in swine: effects on arrhythmogenesis
and arrhythmic threshold
|
- Effects on cardiac
function and arrhythmia threshold of high
dose of skeletal myoblast injection in
swine with myocardial infarction
|
| |
| Flow Cytometry |
- Identification and
characterization of different cell types
involved in vascular injury and repair
following balloon angioplasty and stenting
|
- Comprehensive assessment
of the cellular recruitment, proliferation
and differentiation events involved in
host response to extracellular matrix
scaffold resorbable biomaterial implant
for repair of the infarcted heart
|
- Identification of molecular
targets, oncoproteins and cytokines to
detect modulation of signal transduction
pathways of different antiproliferative,
anti-neoplastic and anti-inflammatory
agents in the investigation of stent restenosis.
Includes monitoring of cytotoxic and cytostatic
effects of key molecular regulators of
the cell cycle
|
| |
| Cardio-Thoracic and Vascular
Surgery |
- Left ventricular free
wall replacement with a tissue-engineered
patch
|
- Polymer aortic valve
replacement
|
- Ischemic heart creation
and cell injection
|
- Pressure sensor implantation
in the heart
|
- Heterotopic heart transplantation
|
- Ischemic hind limb
model and cell injection
|
| |
| Physiology |
- Interventional procedures:
studies involving PTCA, brachytherapy,
and coronary stents (baremetal, drug-eluting
and bioerrodable)
|
- Patch implants in infarcted
myocardium
|
- Broad range of histomorphometry
and histopathology evaluations
|
| |
| Tissue Engineering |
- NIH-sponsored, internally
funded and corporate-sponsored tissue
engineering studies in areas including:
|
o Vascular grafts
|
o Heart valve replacement
|
o Myocardial tissue
repair
|
| |
